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A 15% loss in body weight was set as a humane endpoint

The symptom typically plateaued and began improving as participants entered weeks 4 through 8, suggesting that the body's adjustment mechanisms were active during this window

doi:10.3389/fneur.2013.00193 Ladesich JB, Pottala JV, Romaker A, Harris WS

Glutathione helps mitigate this process by directly neutralizing free radicals and maintaining redox balance within cells

Abnormalities in the expression or function of FOXO6 have been identified as a pathophysiological basis for the development of fasting hyperglycemia and hyperlipidemia, which are serious metabolic complications in diabetic patients